MICROANATOMY

Detailed explanation-1: -What is uremia? Uremia is a dangerous condition that occurs when waste products associated with decreased kidney function build up in your blood. Uremia means “urine in the blood” and refers to the effects of the waste product accumulation. It affects the entire body.

Detailed explanation-2: -Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation of bacterial toxins into the bloodstream and systemic inflammation.

Detailed explanation-3: -Uremic syndrome results from a malfunctioning of various organ systems due to the retention of compounds which, under normal conditions, would be excreted into the urine and/or metabolized by the kidneys. If these compounds are biologically active, they are called uremic toxins.

Detailed explanation-4: -Uremic encephalopathy is a cerebral dysfunction caused by the accumulation of toxins resulting from acute or chronic renal failure.