MICROANATOMY

Detailed explanation-1: -Emphysema is primarily a pathological diagnosis that affects the air spaces distal to the terminal bronchiole. It is characterized by abnormal permanent enlargement of lung air spaces with the destruction of their walls without any fibrosis and destruction of lung parenchyma with loss of elasticity.

Detailed explanation-2: -Hyperinflated lungs are often seen in people with chronic obstructive pulmonary disease (COPD)-a disorder that includes emphysema. Certain lung problems, such as asthma and cystic fibrosis, also can cause hyperinflation.

Detailed explanation-3: -Macrophages are activated by cigarette smoke and recruit neutrophils and CD8+ lymphocytes to cause elastolysis and emphysema.