MUSCLE PHYSIOLOGY

Detailed explanation-1: -synapse, also called neuronal junction, the site of transmission of electric nerve impulses between two nerve cells (neurons) or between a neuron and a gland or muscle cell (effector). A synaptic connection between a neuron and a muscle cell is called a neuromuscular junction.

Detailed explanation-2: -The synaptic cleft-also called synaptic gap-is a gap between the pre-and postsynaptic cells that is about 20 nm (0.02 ) wide. The small volume of the cleft allows neurotransmitter concentration to be raised and lowered rapidly.

Detailed explanation-3: -The synaptic cleft, also known as the synaptic gap, is the space in between the axon of one neuron and the dendrites of another and is where the electrical signal is translated to a chemical signal that can be perceived by the next neuron.

Detailed explanation-4: -The synaptic cleft is the gap between the presynaptic terminal and the postsynaptic muscle membrane, which is filled with a specialized form of extracellular matrix called synaptic basal lamina (Sanes, 2003). This matrix is crucial for the alignment, organization and structural integrity of the NMJ.