MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE CONTRACTION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What causes the tropomyosin to cover back over the actin binding sites?
A
Sarcoplasmic reticulum releases calcium
B
Calcium is pumped back into the sarcoplasmic reticulum
C
Troponin and calcium bind
D
Tropomyosin and calcium bind
Explanation: 

Detailed explanation-1: -Muscle contraction usually stops when signaling from the motor neuron ends, which repolarizes the sarcolemma and T-tubules, and closes the voltage-gated calcium channels in the SR. Ca++ ions are then pumped back into the SR, which causes the tropomyosin to reshield (or re-cover) the binding sites on the actin strands.

Detailed explanation-2: -Muscle contraction ends when calcium ions are pumped back into the sarcoplasmic reticulum, allowing the muscle cell to relax. The concentration of calcium within muscle cells is controlled by the sarcoplasmic reticulum, a unique form of endoplasmic reticulum in the sarcoplasm.

Detailed explanation-3: -Figure 38.18. 1: Muscle contraction: Calcium remains in the sarcoplasmic reticulum until released by a stimulus. Calcium then binds to troponin, causing the troponin to change shape and remove the tropomyosin from the binding sites.

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