MUSCLE PHYSIOLOGY

Detailed explanation-1: -The three-carbon pyruvic acid molecules are converted to a two-carbon molecule attached to Coenzyme A, called acetyl CoA, via the process of pyruvate oxidation. It is the product, acetyl CoA, which enters the Krebs cycle.

Detailed explanation-2: -Acetyl-CoA’s entrance into the citric acid cycle is the beginning of stage III of catabolism. The citric acid cycle produces adenosine triphosphate (ATP), reduced nicotinamide adenine dinucleotide (NADH), reduced flavin adenine dinucleotide (FADH2), and metabolic intermediates for the synthesis of needed compounds.

Detailed explanation-3: -Acetyl CoA transfers its acetyl group to oxaloacetate to form citrate and begin the citric acid cycle. The release of carbon dioxide is coupled with the reduction of NAD+ to NADH in the citric acid cycle.

Detailed explanation-4: -Each pyruvate is broken down into a two carbon acetyl-CoA molecule that enters the citric acid cycle. Each acetyl-CoA molecule produces three and one in the citric acid cycle. This means that two acetyl-CoA (derived from one glucose molecule) produces six and two molecules in the citric acid cycle.