PHYSIOLOGY
MUSCLE ENERGETICS TCA CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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pyruvate molecule in the TCA cycle has the potential to produce ____ ATP
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10
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15
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20
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30
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Explanation:
Detailed explanation-1: -In aerobic conditions, pyruvate enters the citric acid cycle and undergoes oxidative phosphorylation leading to the net production of 32 ATP molecules.
Detailed explanation-2: -2 ATPs are produced in the TCA cycle per glucose molecule (2 acetyl CoA).
Detailed explanation-3: -So, the correct answer is 12 ATP.
Detailed explanation-4: -Isocitrate dehydrogenase catalyzes the rate-limiting reaction in the TCA cycle. Oxidation of 1 pyruvate molecule through the TCA cycle can yield 15 ATP equivalents. Although oxaloacetate and acetyl-CoA are impermeable to mitochondrial membranes, citrate and other intermediates of the cycle are permeable.
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