MUSCLE PHYSIOLOGY

Detailed explanation-1: -Each turn of the cycle forms three NADH molecules and one FADH2 molecule.

Detailed explanation-2: -These electrons come from electron carriers such as NADH and FADH₂, which are produced by the Tricarboxylic Acid Cycle (TCA cycle, also known as the Kreb’s/Citric Acid cycle). In this article, we will outline the steps and regulation of this essential part of cellular physiology.

Detailed explanation-3: -NADH inhibits all the regulatory enzymes in the TCA cycle. Thus, in situations of ETC malfunctioning, NADH accumulates and the TCA cycle shuts down as a consequence. As NADH generates ATP through the ETC and OXPHOS, ATP is also an allosteric inhibitor of pyruvate dehydrogenase (PDH) and IDH.

Detailed explanation-4: -A total of four CO2, six NADHs, two FADH2, and two ATPs are made through the citric acid cycle. NADH and FADH2 are electron carriers that can produce more ATPs later in aerobic respiration.