PHYSIOLOGY
MUSCLE ENERGETICS TCA CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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malate ____
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succinyl CoA ____
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succinate ____
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fumarate ____
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Detailed explanation-1: -Reaction 5: Succinyl-CoA Synthetase The enzyme succinyl-CoA synthetase catalyzes the fifth reaction of the citric acid cycle. In this step a molecule of guanosine triphosphate (GTP) is synthesized.
Detailed explanation-2: -The citric acid cycle enzyme that catalyzes the reaction directly responsible for the production of succinyl-CoA is alpha-ketoglutarate dehydrogenase.
Detailed explanation-3: -Oxidative phosphorylation, the process where electron transport from the energy precursors from the citric acid cycle (step 3) leads to the phosphorylation of ADP, producing ATP.
Detailed explanation-4: -In Krebs cycle, during the conversion of succinyl-CoA to succinic acid, GTP is produced from GDP which being unstable immediately changes to ATP. Since ATP synthesis takes place without entering ETC directly by the substrate, it is known as substrate-level phosphorylation.