MUSCLE PHYSIOLOGY

Detailed explanation-1: -Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.

Detailed explanation-2: -Free acetylcholine within the synaptic cleft is degraded by an enzyme called acetylcholinesterase. This enzyme assures that no excess of acetylcholine remains in the synaptic cleft to cause the continuous activation of receptors. Acetylcholine has different roles and functions at different synapses throughout the body.

Detailed explanation-3: -AChE inhibitors or anti-cholinesterases inhibit the cholinesterase enzyme from breaking down ACh, increasing both the level and duration of the neurotransmitter action.

Detailed explanation-4: -Acetylcholine in the synapse is broken down by an enzyme called acetylcholinesterase into choline and acetate. These products are reabsorbed and recycled so they can be used again in transmitting another chemical message.

Detailed explanation-5: -As mentioned, acetylcholinesterase works by hydrolyzing the ester bond of acetylcholine to produce acetic acid and choline. This process regulates the presence of acetylcholine after it has been released from the nerve cell into the neuromuscular junction to prevent excessive muscle contraction.