MUSCLE PHYSIOLOGY

PHYSIOLOGY

MYASTHENIA GRAVIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
It is believed that the IgG antibodies disrupt the chemical transmission of ACh at the neuromuscular junction by?
A
Accelerating the breakdown of ACh
B
Increasing WBC’s to septic levels
C
Blocking the ACh from the receptor sites of the muscular cell
D
Destroying the receptor sites
Explanation: 

Detailed explanation-1: -In myasthenia gravis, your immune system produces antibodies that block or destroy many of your muscles’ receptor sites for a neurotransmitter called acetylcholine (as-uh-teel-KOH-leen). With fewer receptor sites available, your muscles receive fewer nerve signals, resulting in weakness.

Detailed explanation-2: -Acquired myasthenia Gravis (MG), a disorder of impaired neuromuscular transmission is recognized as an autoimmune disorder, with a majority of the patients having antibodies against acetylcholine receptor (AChR antibodies) in the serum.

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