MUSCLE PHYSIOLOGY

Detailed explanation-1: -Previous studies have shown that acetylcholine induces relaxation in a number of vascular beds by stimulating the release of relaxing factors from the endothelium. Three major endothelium-derived relaxing factors are NO or its related compounds, prostacyclin and EDHFs (11–13).

Detailed explanation-2: -Acetylcholine is involved in many important functions in your body. It plays a major role in voluntary muscle movement all over your body. This is muscle movement you control. Nerve cells stimulate muscle nerve cells, causing muscles to contract.

Detailed explanation-3: -Contraction of smooth muscle by acetylcholine is mediated by activation of muscarinic receptors of which M2 and M3 subtypes are present in longitudinal muscle of guinea pig intestine.