PHYSIOLOGY
NEUROMUSCULAR JUNCTION TRANSMISSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The initiation of end place potential (EPP)
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Ach crosses the synaptic cleft
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NT ache is secreted into the synaptic cleft
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Voltage-gated calcium channels close
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Detailed explanation-1: -This phase is known as the relative refractory period. Once the action potential has finished in the neuromuscular junction, the used acetylcholine is cleared out of the synaptic cleft by the enzyme acetylcholinesterase.
Detailed explanation-2: -end-plate potential (EPP), chemically induced change in electric potential of the motor end plate, the portion of the muscle-cell membrane that lies opposite the terminal of a nerve fibre at the neuromuscular junction.
Detailed explanation-3: -When an action potential reaches a neuromuscular junction, it causes acetylcholine to be released into this synapse. The acetylcholine binds to the nicotinic receptors concentrated on the motor end plate, a specialized area of the muscle fibre’s post-synaptic membrane.
Detailed explanation-4: -1) An AP travels down the axon. to the axon terminal. 2) Electrical gated calcium channels open. 3) Calcium causes the vesicles to. 4) ACH diffuses across the synaptic cleft. 5) ACH binding opens ion channels. 6) If the muscle reaches the threshold (-55mv) at the motor end plate. 7) ACH is broken down by.