PHYSIOLOGY
NEUROMUSCULAR JUNCTION TRANSMISSION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
True
|
|
|
False
|
|
|
Either A or B
|
|
|
None of the above
|
Detailed explanation-1: -Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.
Detailed explanation-2: -Free acetylcholine within the synaptic cleft is degraded by an enzyme called acetylcholinesterase. This enzyme assures that no excess of acetylcholine remains in the synaptic cleft to cause the continuous activation of receptors. Acetylcholine has different roles and functions at different synapses throughout the body.
Detailed explanation-3: -Acetylcholinesterase – Structure and Catalytical Function. AChE is a serine hydrolase mainly found at neuromuscular junctions and cholinergic brain synapses.