PHYSIOLOGY
NEUROMUSCULAR JUNCTION TRANSMISSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Into the synaptic cleft
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Into the synaptic space
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Into the voltage-gated calcium channel
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Into the primary cleft
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Detailed explanation-1: -At the presynaptic terminal, acetylcholine storage occurs within the presynaptic vesicle. With the stimulation of the presynaptic terminal, acetylcholine is released from the vesicles and into the synaptic cleft, where the neurotransmitter is free to bind with receptors.
Detailed explanation-2: -Where does acetylcholine (ACh) work? Acetylcholine is released both in your central nervous system (CNS), your brain and spinal cord, as well as in your peripheral nervous system (the nerves that branch out from your CNS and connect with all other parts of your body, including muscles and organs).
Detailed explanation-3: -When the neurotransmitter has been secreted into the synaptic cleft, it binds to specific receptors on the postsynaptic cell, thereby generating a postsynaptic electrical signal, as described in much more detail in Chapter 7.
Detailed explanation-4: -Introduction. Neurotransmitter release from presynaptic nerve terminals is mediated by the fusion of neurotransmitter-filled synaptic vesicles with the plasma membrane. Synaptic vesicle fusion is tightly coupled to voltage-induced Ca2 + influx and has a latency on the microsecond timescale.