..... The replacement of the multi-layered flat epithelium with secretory columnar epithelium in the lower esophagus of patients who are exposed to the infiltration of acid from the stomach into the esophagus (reflux) is an example of

PATHOLOGY AND GENETICS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

____ The replacement of the multi-layered flat epithelium with secretory columnar epithelium in the lower esophagus of patients who are exposed to the infiltration of acid from the stomach into the esophagus (reflux) is an example of

A	Neoplasia
B	Hyperplasia
C	Dysplasia
D	Metaplasia

Explanation:

Detailed explanation-1: -The process of cell change from flat, layered squamous to tall columnar epithelium is an example of metaplasia. Columnar cells are more resistant to acid and pepsin and the metaplasia may be a defense against refluxed acid.

Detailed explanation-2: -Barrett’s esophagus is defined as columnar metaplasia of the esophagus. There is worldwide controversy regarding the diagnostic criteria of BE, mainly with regard to the requirement to histologically identify goblet cells in biopsies.

Detailed explanation-3: -Metaplasia is the conversion of one adult tissue type into another, related and more durable, tissue type. The most prevalent examples are conversion of fibrous tissue into bone, or columnar mucosal epithelium into stratified squamous epithelium.

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PATHOLOGY AND GENETICS