NURSING ANM AND GNM

Detailed explanation-1: -Cross-linking of collagen refers to the ability of collagen fibrils to form strong chemical bonds with adjacent fibrils. In the cornea, collagen cross-linking occurs naturally with aging due to an oxidative deamination reaction that takes place within the end chains of the collagen.

Detailed explanation-2: -The cross-linking theory suggests that these molecular issues arise when glucose binds to protein. This process occurs under the presence of oxygen, and as we age there are increased odds that oxygen comes in contact with glucose and protein to activate the cross-linking transition.

Detailed explanation-3: -The general consensus is that as collagen ages there is an increase in the stiffness with loss of elasticity and that this is due to an increase in covalent intermolecular cross-linking between collagen molecules which develops with age (1).

Detailed explanation-4: -Main factors which affect chemical crosslinking are the concentration of the crosslinking agents and the reaction duration. High concentrations of crosslinking agents induce rapid crosslinking.