NURSING ANM AND GNM

Detailed explanation-1: -Second, INH inhibits the enzyme pyridoxine phosphokinase; this enzyme is necessary to activate pyridoxine to pyridoxal 5’ phosphate, the cofactor in many “pyridoxine-dependent” reactions. Functional pyridoxine deficiency is the likely mechanism of INH-induced peripheral neuropathy.

Detailed explanation-2: -Isoniazid competes for these same enzymes, which reduces the amount of the activated form of pyridoxine in the body. Isoniazid metabolites also react with pyridoxine to deactivate it. Taking isoniazid thus reduces the amount of pyridoxine that the body effectively has, and this deficiency causes neuropathy.

Detailed explanation-3: -First, INH metabolites directly inactivate pyridoxine species. It also acts by inhibiting the enzyme pyridoxine phosphokinase which is a necessary enzyme to convert pyridoxine to its active form of pyridoxal 5’ phosphate which is a very important cofactor in many reactions.

Detailed explanation-4: -Why might I need to take Vitamin B6 (Pyridoxine) at the same time? Vitamin B6 will help prevent numbness and tingling in your fingers and toes that can be caused by INH.