PATHOLOGY

Detailed explanation-1: -If cells are no longer needed, they commit suicide by activating an intracellular death program. This process is therefore called programmed cell death, although it is more commonly called apoptosis (from a Greek word meaning “falling off, ‘’ as leaves from a tree).

Detailed explanation-2: -A type of programmed cell death is observed in multicellular organisms known as apoptosis.

Detailed explanation-3: -Apoptosis is a physiological process of cell death by which a single cell may be eliminated from the living tissue. Since the process is mediated by specific proteins encoded in the host’s genome, it is also a programmed cell death.

Detailed explanation-4: -Drugs and irradiation used in chemotherapy leads to DNA damage, which results in triggering apoptosis through the p53 dependent pathway. The apoptosis, stages are includes nuclear DNA fragmentation, cell shrinkage, chromatin condensation, membrane blebbing, and the formation of apoptotic bodies.