PATHOLOGY

Detailed explanation-1: -In multicellular organisms, cells that are no longer needed or are a threat to the organism are destroyed by a tightly regulated cell suicide process known as programmed cell death, or apoptosis.

Detailed explanation-2: -Apoptosis describes the orchestrated collapse of a cell characterised by membrane blebbing, cell shrinkage, condensation of chromatin, and fragmentation of DNA followed by rapid engulfment of the corpse by neighbouring cells.

Detailed explanation-3: -There are 4 stages of apoptosis: the initiation or stimulus for cell death, the active programmed cell death when the events become irreversible, phagocytosis of the dead cellular material, and inhibitory mechanisms of apoptosis.

Detailed explanation-4: -Cell shrinks. Cell fragments. Cytoskeleton collapses. Nuclear envelope disassembles. Cells release apoptotic bodies. 28-Apr-2013