PATHOLOGY

Detailed explanation-1: -Within the nucleoplasm, the NUCLEOLUS manufactures RIBOSOMES, structures in which proteins are assembled.

Detailed explanation-2: -The ribosome is universally responsible for synthesizing proteins by translating the genetic code transcribed in mRNA into an amino acid sequence. Ribosomes use cellular accessory proteins, soluble transfer RNAs, and metabolic energy to accomplish the initiation, elongation, and termination of peptide synthesis.

Detailed explanation-3: -Eukaryote ribosomes are produced and assembled in the nucleolus. Ribosomal proteins enter the nucleolus and combine with the four rRNA strands to create the two ribosomal subunits (one small and one large) that will make up the completed ribosome (see Figure 1).

Detailed explanation-4: -In eukaryotes (but not in prokaryotes), some of the ribosomes are attached to internal membranes, where they synthesize the proteins that will later reside in those membranes, or are destined for secretion (Figure 6).

Detailed explanation-5: -The ER serves as the workbench of the cell for building itself and other membranes, and thus it is endowed with the enzymes necessary for lipid synthesis and protein glycosylation and the ribosomes necessary for protein synthesis.