PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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G1 checkpoint
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S checkpoint
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G2 checkpoint
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M checkpoint
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Detailed explanation-1: -The G1/S checkpoint prevents cells from entering the S phase in the presence of the DNA damage by inhibiting the initiation of replication. There are two signal transduction pathways, one to initiate and one to maintain the G1/S arrest [1].
Detailed explanation-2: -At the G1 checkpoint, cells decide whether or not to proceed with division based on factors such as: Cell size. Nutrients. Growth factors.
Detailed explanation-3: -p53 is a multi-functional protein that has a major impact on the commitment of a cell to division because it acts when there is damaged DNA in cells that are undergoing the preparatory processes during G1. If damaged DNA is detected, p53 halts the cell cycle and recruits enzymes to repair the DNA.