PATHOLOGY

Detailed explanation-1: -Inactivation of tumor suppressor genes therefore leads to tumor development by eliminating negative regulatory proteins. In several cases, tumor suppressor proteins inhibit the same cell regulatory pathways that are stimulated by the products of oncogenes.

Detailed explanation-2: -Tumor suppressor genes are normal genes that slow down cell division or tell cells to die at the right time (a process known as apoptosis or programmed cell death). When tumor suppressor genes don’t work properly, cells can grow out of control, which can lead to cancer.

Detailed explanation-3: -When a tumor suppressor gene is mutated, this can lead to tumor formation or growth. Properties of tumor suppressor genes include: Both copies of a specific tumor suppressor gene pair need to be mutated to cause a change in cell growth and tumor formation to happen.

Detailed explanation-4: -Tumor-suppressor genes, when inactivated, are linked to uncontrolled proliferation of cancer cells. Normally, they regulate the cell cycle, slow proliferation that results from growth signaling, stop cell division if cells are damaged, and prevent gene mutations. Because of this, they are also called anti-oncogenes.