PATHOLOGY

Detailed explanation-1: -Necrosis is the pattern of cell death that occurs in response to injuries such as hypoxia, extremes of temperature, toxins, physical trauma, and infection with lytic viruses. The injury to a cell is said to be irreversible if it kills the cell. If the damage is a bit less, the injury is said to be reversible.

Detailed explanation-2: -Treatment can slow the progress of avascular necrosis, but there is no cure. Most people who have avascular necrosis eventually have surgery, including joint replacement. People who have avascular necrosis can also develop severe osteoarthritis.

Detailed explanation-3: -Irreversible Cellular Injury is cell death via apoptosis or necrosis that is permanent (There are no zombie cells). Each type of cellular damage is characterized by specific cellular changes. Reversible cellular injury is most often described in the setting of ischemia.

Detailed explanation-4: -The effects on ATP depletion are not reversible but cells in these early stages of necrosis do not progress further when DIF-1 is removed. Later steps in the progression of DIF-1-induced necrotic cell death include lysosome permeabilization and ultimately plasma membrane rupture.