PATHOLOGY

Detailed explanation-1: -Necrosis is a type of irreversible cell injury characterized by cytoplasmic swelling, damage to the plasma membrane and organelle destruction. All of which cause cell death.

Detailed explanation-2: -Two phenomena consistently characterize irreversible injury. The first is the inability to reverse mitochondrial dysfunction (lack of oxidative phosphorylation and ATP generation) even upon restoration of oxygen; the second is the development of profound disturbances in membrane function.

Detailed explanation-3: -Cell injury is classified as reversible if the injured cell can regain homeostasis and return to a morphologically (and functionally) normal state. Acute cell swelling is the classic morphologic change in reversible injury; however, it is also the typical early change of irreversible cell injury.

Detailed explanation-4: -Necrosis. Necrosis is characterised by cytoplasmic swelling, irreversible damage to the plasma membrane, and organelle breakdown leading to cell death.