PATHOLOGY

Detailed explanation-1: -In mitosis, the cohesion of sister chromatids at the centromere lapses at the end of metaphase, enabling the daughter chromosomes to move apart towards the two poles of the spindle. In meiosis, in contrast, the chromatids remain joined at the centromere at the first anaphase.

Detailed explanation-2: -(a) The centromere is the region present in a chromosome that separated a chromatid into two distinct arms. This means that the centromere is the portion of a chromosome where chromatids remain attached before the process of cell division initiates.

Detailed explanation-3: -Chromatid The two “sister” chromatids are joined at a constricted region of the chromosome called the centromere. During cell division, spindle fibers attach to the centromere and pull each of the sister chromatids to opposite sides of the cell.

Detailed explanation-4: -Mitosis and meiosis are essential processes that occur during development. Throughout these processes, cohesion is required to keep the sister chromatids together until their separation at anaphase.

Detailed explanation-5: -The centromere is the chromosome region that attaches to a spindle fibre at metaphase of mitosis or meiosis and moves to the spindle pole at anaphase, pulling the rest of the chromosome behind it.