PATHOLOGY MCQ
CELL DAMAGE
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Light microscopic changes:cell swelling, fat accumulation
|
|
|
Ultra structural changes:cell membrane alterations, mitochondrial swelling, RER swelling and ribosomal detachment.
|
|
|
Light microscopic changes:Loss of RNA, cytoplasmic vacuolisation, chromatin clumping.
|
|
|
Ultra structural changes:Membrane disruption, mitochondrial amorphous densities, nuclear changes (pyknosis-shrinkage, karyorrhexis-fragmentation, karyolysis-fading).
|
Detailed explanation-1: -The ultrastructural changes of reversible cell injury include: Blebbing. Blunting. distortion of microvilli.
Detailed explanation-2: -Morphology of Cell Injury – Adaptive Changes (Atrophy, Hypertrophy, Hyperplasia, Metaplasia, Dysplasia)
Detailed explanation-3: -It is possible for some degree of mitochondrial swelling to occur and this alteration can be a reversible, prelethal cellular change. Therefore, observations about mitochondrial swelling should not evitably lead to conclusions that the cell is dying or dead.
Detailed explanation-4: -When cells are injured, one of two patterns will generally result: reversible cell injury leading to adaptation of the cells and tissue, or irreversible cell injury leading to cell death and tissue damage. When cells adapt to injury, their adaptive changes can be atrophy, hypertrophy, hyperplasia, or metaplasia.