PATHOLOGY

Detailed explanation-1: -Metaphase leads to anaphase, during which each chromosome’s sister chromatids separate and move to opposite poles of the cell. Enzymatic breakdown of cohesin-which linked the sister chromatids together during prophase-causes this separation to occur.

Detailed explanation-2: -Anaphase II: During anaphase II, the centromere splits, freeing the sister chromatids from each other. At this point, spindle fibers begin to shorten, pulling the newly-separated sister chromatids towards opposite ends of the cell.

Detailed explanation-3: -Sister chromatids separate during anaphase I.

Detailed explanation-4: -Anaphase. The sister chromatids separate from one another and are pulled towards opposite poles of the cell.

Detailed explanation-5: -Both mitotic anaphase and meiotic anaphase II involves the separation of sister chromatids towards the opposite poles of the cell.