PATHOLOGY

Detailed explanation-1: -G1 checkpoint is also known as the restriction point at which the cell irreversibly commits to the cell division process. Cell set up certain requirements to be fulfilled by the cell to pass the check points. External factor such as growth factors play a vital role in carrying the cell past the G1 checkpoint.

Detailed explanation-2: -The G 1start subscript, 1, end subscript checkpoint is the main decision point for a cell – that is, the primary point at which it must choose whether or not to divide. Once the cell passes the G 1start subscript, 1, end subscript checkpoint and enters S phase, it becomes irreversibly committed to division.

Detailed explanation-3: -The G2 checkpoint prevents cells from entering mitosis when DNA is damaged, providing an opportunity for repair and stopping the proliferation of damaged cells. Because the G2 checkpoint helps to maintain genomic stability, it is an important focus in understanding the molecular causes of cancer.

Detailed explanation-4: -1: Internal Checkpoints During the Cell Cycle: The cell cycle is controlled at three checkpoints. The integrity of the DNA is assessed at the G1 checkpoint. Proper chromosome duplication is assessed at the G2 checkpoint. Attachment of each kinetochore to a spindle fiber is assessed at the M checkpoint.