PATHOLOGY

Detailed explanation-1: -The released chemical mediators include (1) vasoactive amines such as histamine and serotonin, (2) peptide (e.g., bradykinin), and (3) eicosanoids (e.g., thromboxanes, leukotrienes, and prostaglandins).

Detailed explanation-2: -Histamine is a potent inflammatory mediator, commonly associated with allergic reactions, promoting vascular and tissue changes and possessing high chemoattractant activity.

Detailed explanation-3: -The most important kinin is bradykinin, which increases vascular permeability and vasodilation and, importantly, activates phospholipase A2 (PLA2) to liberate arachidonic acid (AA). Bradykinin is also a major mediator involved in the pain response.

Detailed explanation-4: -Histamine is stored in the granules of mast cells, basophils, platelets. This histamine is released from these cells by the stimuli inducing acute inflammation, anaphylatoxins, and histamine releasing factors.