PATHOLOGY

Detailed explanation-1: -During mitosis, microtubules similarly extend outward from duplicated centrosomes to form the mitotic spindle, which is responsible for the separation and distribution of chromosomes to daughter cells.

Detailed explanation-2: -And when the chromosomes are condensing to undergo mitosis, the centrioles form the areas that mitotic spindle forms from. And those mitotic spindles go and attach to each of the chromosomes and pull the chromosomes to opposite ends of the cell to allow cytokinesis, then, to occur.

Detailed explanation-3: -Centrioles help to arrange the microtubules that move chromosomes during cell division to ensure each daughter cell receives the appropriate number of chromosomes. Centrioles are also important for the formation of cell structures known as cilia and flagella.

Detailed explanation-4: -The spindle is a complex microtubule-based superstructure responsible for chromosome movement and segregation during mitosis and meiosis (McIntosh and Koonce 1989; Mitchison 1989a; Rieder 1991; Hyman and Karsenti 1996; Compton 2000).

Detailed explanation-5: -Centrioles recruit and organize pericentriolar material. As a result, centrioles dominate microtubule organization and spindle assembly in cells born with centrosomes. Centrioles duplicate in concert with chromosomes during the cell cycle.