PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which checkpoint ensures sister chromatids are positioned to be split correctly?
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G1 checkpoint
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G2 checkpoint
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S checkpoint
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M checkpoint
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Explanation:
Detailed explanation-1: -The segregation of sister chromatids at anaphase is under the mechanical control of the mitotic spindle.
Detailed explanation-2: -The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before chromosomes have achieved bipolar attachment to the spindle.
Detailed explanation-3: -G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they follow normal transition to the M phase.
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