PATHOLOGY

Detailed explanation-1: -The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.

Detailed explanation-2: -For example, TP53 is an important tumor suppressor gene. It codes for the p53 protein, which helps keep cell division under control. Inherited changes in the TP53 gene can lead to Li-Fraumeni syndrome.

Detailed explanation-3: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

Detailed explanation-4: -The p53 proto-oncogene can act as a suppressor of transformation.