PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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chromosomes begin to relax
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new nuclear membranes form around each set of chromosomes
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spindle fibers attach to chromosomes
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a cleavage furrow forms where the cell will separate
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Detailed explanation-1: -The spindle continues to elongate during telophase, as the chromosomes arriving at the poles are released from the spindle microtubules and the nuclear envelope re-forms around them.
Detailed explanation-2: -During mitosis, spindle fibers attach to the centromere via the kinetochore. Kinetochores generate kinetochore fibers, which attach sister chromatids to spindle fibers. Kinetochore fibers and spindle polar fibers work together to manipulate and separate chromosomes during mitosis and meiosis.
Detailed explanation-3: -The spindle fibers are made up of microtubules and accessory filaments and they are responsible for the separation of the homologous chromosomes in meiosis I. In conditions where the spindle fibers failed to attach to the chromosomes, the proper separation of the chromosomes will not happen (non-disjunction).