PATHOLOGY

Detailed explanation-1: -Prostaglandins are found in most tissues and organs. They are produced by almost all nucleated cells. They are autocrine and paracrine lipid mediators that act upon platelets, endothelium, uterine and mast cells. They are synthesized in the cell from the fatty acid arachidonic acid.

Detailed explanation-2: -In the cortex, major sites of prostaglandin synthesis include arteries and arterioles as well as the glomerulus. At these sites, prostaglandins are important in maintaining blood flow and glomerular filtration, especially during conditions of enhanced vasoconstrictor activity.

Detailed explanation-3: -Prostaglandins are hormone-like substances that affect several bodily functions, including inflammation, pain and uterine contractions. Healthcare providers use synthetic forms of prostaglandins to treat several conditions. They also use medications to block the effects of prostaglandins.