PATHOLOGY

Detailed explanation-1: -We inherit genes from both our parents. If a parent has a gene fault, then each child has a 1 in 2 chance (50%) of inheriting it. So, some children will have the faulty gene and an increased risk of developing cancer and some children won’t.

Detailed explanation-2: -Daughters have a 50% chance of inheriting the mutated X-linked gene from their mother and a 100% chance of inheriting the mutated X-linked gene from their father. Sons have a 50% chance of inheriting the mutated X-linked gene from their mother and a 0% chance of inheriting the mutated X-linked gene from their father.

Detailed explanation-3: -Many individuals fear that their risk of cancer is higher, as well. However, according to the American Cancer Society, most cancers are not passed down through families. The number of inherited cancer cases is only about 5 to 10%.

Detailed explanation-4: -The X-chromosome is known to contain many genes related to cancer [7]. One such group of genes are the “cancer-testis” genes, which, although only normally expressed in adult tissue by the testes, have been observed to also be expressed by many tumors, including those of the ovary [8, 9].