PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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FAD is the result of a genetic change in one or more chromosomes.
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Natural selection will continue to reduce the incidence of FAD.
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FAD affects only the genes of middle-aged people.
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Deletion of one amino acid causes FAD.
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Detailed explanation-1: -Young-onset (also called early-onset) Alzheimer’s is an uncommon form of dementia that affects people younger than age 65. About 5% to 6% of people with Alzheimer’s disease develop symptoms before age 65.
Detailed explanation-2: -Less than 5% of Alzheimer’s disease (AD) is caused by a single genetic mutation that is transmitted through families. In these families, people usually show symptoms well before the age of 65 and symptoms sometimes begin as early as the 30s or 40s.
Detailed explanation-3: -Genetic (familial) Alzheimer disease. A few hundred people have genes that directly contribute to Alzheimer disease. These people start showing symptoms of the disease in their 30s, 40s, or 50s.
Detailed explanation-4: -Alzheimer’s disease mainly affects adults who are older-up to 10% of those over age 65 and about 50% of people older than 85 have the disease. Family history is an important risk factor. Approximately 60% to 80% of people with dementia have this type.