PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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figure out the role of a protein
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understand genetic diseases
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disable genes
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all three options
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Detailed explanation-1: -CRISPR can change DNA in humans and animals.
Detailed explanation-2: -The CRISPR defense mechanism protects bacteria from repeated viral attacks via three basic stages: adaptation (spacer acquisition), crRNA synthesis (expression), and target interference. CRISPR loci are an array of short repeated sequences found in chromosomal or plasmid DNA of prokaryotes.
Detailed explanation-3: -Three major types of CRISPR-Cas systems are at the top of the classification hierarchy. The three types are readily distinguishable by virtue of the presence of three unique signature genes: Cas3 in type I systems, Cas9 in type II, and Cas10 in type III [5].
Detailed explanation-4: -Compared with the traditional gene-editing technology, CRISPR-Cas9 has a higher gene-editing efficiency, lower off-target effect, and no DNA integration, so it is an ideal gene-editing technology (Yang and Yang, 2021).