PATHOLOGY

PATHOLOGY MCQ

GENETICS AND DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Hemophilia, a bleeding disorder, is a human sex-linked trait. A man with hemophilia (XhY) marries a woman who carries one gene for the disorder (XHXh). What are the chances that their first born son will have hemophilia? You need to work a Punnett square on paper. (3B3)
A
0%
B
50%
C
75%
D
100%
Explanation: 

Detailed explanation-1: -A man who has hemophilia and a woman who is a carrier have: a 25% (one in four) chance of having a son with hemophilia. a 25% chance of having a son with normal blood clotting. a 25% chance of having a daughter who is a carrier.

Detailed explanation-2: -If a mother is heterozygous (a carrier) for hemophilia and the father does not have hemophilia, each son has a 1 in 2 (50%) chance of getting his mother’s hemophilia allele and having hemophilia. Each daughter has a 1 in 2 (50%) chance of getting her mother’s hemophilia allele and being heterozygous.

Detailed explanation-3: -Answer and Explanation: If a male who is a hemophiliac marries a woman who is a carrier for hemophilia, the chance that their male children will not have hemophilia is 50%.

Detailed explanation-4: -A female who is a carrier has a 50-50 chance that each male child will have hemophilia. There is a 50-50 chance that each female child will be a carrier (Picture 2).

There is 1 question to complete.