PATHOLOGY

PATHOLOGY MCQ

GENETICS AND DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
How are the X and Y chromosomes different?
A
Only one is an autosome
B
The X is smaller than the Y
C
The Y carries fewer genes than the X
D
Only females have Y
Explanation: 

Detailed explanation-1: -The Y chromosome is important in determining a person’s biological gender. But it has much less of a say in someone’s genetic makeup, since the X chromosome likely has more than 1, 000 genes whereas the Y chromosome has fewer than 80.

Detailed explanation-2: -To keep from getting the SRY gene “fixed", the Y chromosome stopped recombining with most of the X chromosome. While this saved the SRY gene, it was disastrous for the Y chromosome. The Y chromosome shrunk and shrunk and shed over 1000 genes to its 78 today.

Detailed explanation-3: -Deprived of the benefits of recombination, Y chromosomal genes degenerate over time and are eventually lost from the genome. Despite this, recent research has shown that the Y chromosome has developed some pretty convincing mechanisms to “put the brakes on", slowing the rate of gene loss to a possible standstill.

Detailed explanation-4: -The Y chromosome is a puny bit of DNA that has only a few genes. And the genes it does have mostly deal with being male. So the only traits that are passed from father to son through the Y are those that turn an embryo into a male and those that make a man fertile once he reaches puberty.

Detailed explanation-5: -The key difference between X chromosome and Y chromosome is that X chromosome does not contain SRY gene (sex-determining region Y), which is the male determining gene while Y chromosome has SRY gene. X chromosome is larger in size and contains a higher number of genes compared to Y chromosome.

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