Huntigtons disease is a genetic disorder caused by a dominant lethal allele. The condition is a progressive breakdown of nerve cells that causes uncontrolled movement. The disorder can be found on the dominant H allele (which is rare ..... because usually disorders are recessive!). If the father is homozygous dominant for the trait and the mother does not have the trait, what is the phenotypic probability for their children?

GENETICS AND DISEASE

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Huntigton’s disease is a genetic disorder caused by a dominant lethal allele. The condition is a progressive breakdown of nerve cells that causes uncontrolled movement. The disorder can be found on the dominant H allele (which is rare ____ because usually disorders are recessive!). If the father is homozygous dominant for the trait and the mother does not have the trait, what is the phenotypic probability for their children?

A	1 HH:1 Hh
B	1 Hh:1 hh
C	1 HH:2 Hh:1 hh
D	1 Have Huntington’s:1 Does not have Huntington’s
E	1 Have Huntington’s

Explanation:

Detailed explanation-1: -Huntington’s disease is a progressive brain disorder caused by a single defective gene on chromosome 4-one of the 23 human chromosomes that carry a person’s entire genetic code. This defect is “dominant, ‘’ meaning that anyone who inherits it from a parent with Huntington’s will eventually develop the disease.

Detailed explanation-2: -Huntington’s disease is caused by a faulty gene. Cells in parts of the brain are very sensitive to the effects of the faulty gene. This makes them function poorly and eventually die. A parent with the Huntington’s disease gene has one good copy of the gene and one faulty copy.

Detailed explanation-3: -Because the onset of Huntington’s disease is slow, individuals carrying the allele can pass it on to their offspring. This allows the allele to be maintained in the population. Dominant traits can also be maintained in the population through recurrent mutations or if the penetrance of the gene is less than 100%.

Detailed explanation-4: -Keep life simple-Rest, Exercise, Nutrition, A daily laugh Carry earplugs with you when you are out (Some people with HD are sensitive to noise) Carry calendars with you to write down everything you must do for the day and any information you get from other people. More items •02-Jun-2021

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PATHOLOGY

PATHOLOGY MCQ

GENETICS AND DISEASE