PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Individuals who inherit the mutated form of the gene usually develop serious health problems.
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Healthy individuals, with the normal form of the CFTR gene, can pass on a mutated form.
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Either A or B
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None of the above
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Detailed explanation-1: -Which of the following would provide evidence that the mutated form of the CFTR protein is harmful to humans? Individuals who inherit the mutated form of the gene usually develop serious health problems. A genetic mutation will most immediately affect which of the following?
Detailed explanation-2: -All people have two copies of the CFTR gene, and there must be mutations in both copies to cause CF. More than 1, 700 mutations of the CFTR gene have been identified. Although some are common, others are rare and found in only a few people.
Detailed explanation-3: -Mutations in the CFTR gene disrupt the function of the chloride channel, preventing the usual flow of chloride ions and water into and out of cells. As a result, cells in the male genital tract produce mucus that is abnormally thick and sticky.