PATHOLOGY

Detailed explanation-1: -Studies have confirmed an increase in several genetic disorders due to inbreeding such as blindness, hearing loss, neonatal diabetes, limb malformations, disorders of sex development, schizophrenia and several others.

Detailed explanation-2: -Continuous inbreeding results in increased homozygosity and produces homozygous stocks of dominant or recessive genes and eliminates heterozygosity from the population.

Detailed explanation-3: -Examples of specific genetic disorders associated with inbreeding include schizophrenia, limb malformation, blindness, congenital heart disease, and neonatal diabetes. The House of Habsburg may be the best example of the effects of inbreeding in humans.

Detailed explanation-4: -The primary effect of inbreeding is to produce homozygosis. As a consequence of this increased homozygosis, the individuals may show a decline in performance. This decline in performance is perhaps the most important single limiting factor in the development and maintenance of inbred lines.