PATHOLOGY MCQ
GENETICS AND DISEASE
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Lethal disorders caused by dominant alleles are usually more severe than lethal disorders caused by recessive alleles.
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Unlike lethal disorders caused by recessive alleles, lethal disorders caused by dominant alleles usually cause death of the embryo.
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Most individuals carrying a lethal dominant allele have the disorder and die before they reproduce.
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The presence of a dominant lethal allele causes sterility.
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Detailed explanation-1: -Dominant lethal alleles are very rare because, as you might expect, the allele only lasts one generation and is not transmitted. However, just as the recessive lethal allele might not immediately manifest the phenotype of death, dominant lethal alleles also might not be expressed until adulthood.
Detailed explanation-2: -Most individuals carrying a lethal dominant allele have the disorder and die before they reproduce, whereas individuals carrying a lethal recessive allele are more likely to be healthy and reproduce.
Detailed explanation-3: -Explain why disorders caused by dominant alleles on autosomes are less common than those caused by recessive alleles on autosomes? because there are also carriers and if the disorder was dominant Kt would be more common. Describe his the expression of sex-linked genes can differ between males and females.
Detailed explanation-4: -Whether an allele is dominant or not does not affect how common a trait is. Now of course traits can become more common over time. The changes just don’t have anything to do with whether the trait is dominant or not.
Detailed explanation-5: -Lethal genes can be recessive, as in the aforementioned mouse experiments. Lethal genes can also be dominant, conditional, semilethal, or synthetic, depending on the gene or genes involved.