PATHOLOGY

Detailed explanation-1: -If only one parent has the altered gene, none of their children will develop the condition, but each child has a 50 per cent chance of being a genetic carrier of TSD. Tay-Sachs disease is most commonly observed in individuals of Jewish and French-Canadian descent, but can also occur in people from other backgrounds.

Detailed explanation-2: -1 in 2 (50%) chance the child inherits a faulty gene from one parent and becomes a carrier, but won’t have the condition themselves. 1 in 4 (25%) chance the child inherits a faulty gene from both parents and develops Tay-Sachs disease.

Detailed explanation-3: -When both parents carry the defective Tay-Sachs gene, a child has a 25% chance of developing the disease. The child must receive two copies of the defective gene, one from each parent, in order to become sick. If only one parent passes the defective gene to the child, the child is called a carrier.

Detailed explanation-4: -Tay-Sachs disease is a genetic disorder that is passed from parents to their children. It occurs when a child inherits a flaw (mutation) in the HEXA gene from both parents. The genetic change that causes Tay-Sachs disease results in a deficiency of the enzyme beta-hexosaminidase A.