PATHOLOGY

Detailed explanation-1: -elegans consists of 12 chromosomes in hermaphrodites, five pairs of autosomes and two sex chromosomes, and 11 chromosomes in males, which have a single sex chromosome.

Detailed explanation-2: -3.1. Most nematodes have haploid chromosome numbers of n=4–12 (Walton, 1959).

Detailed explanation-3: -Importantly, C. elegans is a tractable genetic system that normally exists as a diploid, contains only five autosomes (A) and one sex chromosome (X) per genome, is transparent allowing for in vivo observation of biological processes, and has a short life cycle of 3-4 days (from egg to sexually mature adult).

Detailed explanation-4: -For C. elegans, the mitochondrial genome (13, 794 bp) has been fully sequenced (Okimoto et al. 1992). The nuclear genome contains approximately 100 × 106 base pairs, organized into six chromosomes ranging in size from 14 × 106 to 22 × 106 base pairs (Coulson et al.