PATHOLOGY

Detailed explanation-1: -Sickle cell disorder (SCD), also known as drepanocytosis, is a quadrumvirate of anemia and its sequelae, pain syndromes, organ damage including infection, and comorbid conditions. It is a chronic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape.

Detailed explanation-2: -Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

Detailed explanation-3: -Sickle cell disease is a genetic disorder caused by mutations in the beta globin gene that leads to faulty hemoglobin protein, called hemoglobin S. Hemoglobin S changes flexible red blood cells into rigid, sickle-shaped cells.

Detailed explanation-4: -If you have sickle cell disease, your red blood cells are crescent-or “sickle”-shaped. These cells do not bend or move easily and can block blood flow to the rest of your body.

Detailed explanation-5: -Sickle cell anemia is an inherited disorder in which abnormal hemoglobin (the red pigment inside red blood cells) is produced. The abnormal hemoglobin causes red blood cells to assume a sickle shape, like the ones seen in this photomicrograph.