PATHOLOGY

Detailed explanation-1: -HbSS. People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin “S.” Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. This is commonly called sickle cell anemia and is usually the most severe form of the disease.

Detailed explanation-2: -Sickle cell disease (SCD) is a genetic disorder caused by a mutation in both copies of a person’s HBB gene. This gene encodes a component of hemoglobin, the oxygen-carrying protein in red blood cells.

Detailed explanation-3: -Sickle cell disorder (SCD), also known as drepanocytosis, is a quadrumvirate of anemia and its sequelae, pain syndromes, organ damage including infection, and comorbid conditions. It is a chronic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape.