PATHOLOGY

Detailed explanation-1: -Huntington’s disease is caused by an inherited difference in a single gene. Huntington’s disease is an autosomal dominant disorder, which means that a person needs only one copy of the nontypical gene to develop the disorder.

Detailed explanation-2: -This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. An affected person usually inherits the altered gene from one affected parent.

Detailed explanation-3: -HD is called a dominant trait because individuals with just one copy of the HD allele typically develop HD symptoms. The HD allele (with many CAG repeats) is dominant over the non-HD allele (with few CAG repeats). Again, an individual need have only one copy of the HD allele to inherit the disease.

Detailed explanation-4: -Each child of a parent with HD has a 50 percent chance of inheriting the HD gene. A child who does not inherit the HD gene will not develop the disease, and generally, they cannot pass it on to their children or other future generations.