PATHOLOGY

Detailed explanation-1: -Huntington’s disease is caused by an inherited difference in a single gene. Huntington’s disease is an autosomal dominant disorder, which means that a person needs only one copy of the nontypical gene to develop the disorder.

Detailed explanation-2: -Huntington’s Disease Huntington’s disease is inherited as an autosomal dominant trait, meaning that a single mutated copy of the responsible gene (called HTT) is sufficient to cause the disease.

Detailed explanation-3: -This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. An affected person usually inherits the altered gene from one affected parent.

Detailed explanation-4: -Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a mutation in the HD gene on chromosome 4. The causative mutation is an expansion of the CAG repeat at the 5′ end of the HD gene, resulting in abnormally expanded polyglutamine chain.

Detailed explanation-5: -“Dominant” means that a single copy of the mutated gene (from one parent) is enough to cause the disorder. A child of a person affected by an autosomal dominant condition has a 50% chance of being affected by that condition via inheritance of a dominant allele.