PATHOLOGY

Detailed explanation-1: -Since males only have one X chromosome, any mutated gene on the X chromosome, dominant or recessive, will result in disease. Because females have two copies of X-linked genes, they will not be affected by inheriting of a single recessive mutation on an X-linked gene.

Detailed explanation-2: -Females have two X chromosomes in their cells, while males have one X and one Y. In the case of an X-linked disease, it is usually males that are affected because they have a single copy of the X chromosome that carries the disease-causing mutation.

Detailed explanation-3: -X-linked recessive conditions most often occur in males. X-linked recessive inheritance is a way a genetic trait or condition can be passed down from parent to child through mutations (changes) in a gene on the X chromosome.

Detailed explanation-4: -Males can only get an X chromosome from their mother whilst females get an X chromosome from both parents. As a result, females tend to show higher prevalence of X-linked dominant disorders because they have more of a chance to inherit a faulty X chromosome.

Detailed explanation-5: -X-linked recessive inheritance refers to genetic conditions associated with mutations in genes on the X chromosome. A male carrying such a mutation will be affected, because he carries only one X chromosome. A female carrying a mutation in one gene, with a normal gene on the other X chromosome, is generally unaffected.